Role of non-coding RNAs in modulating the response of cancer cells to paclitaxel treatment

Paclitaxel is a chemotherapeutic substance that administered for treatment of an extensive spectrum human malignancies. In spite its potent short-term effects against tumor cells, resistance to paclitaxel occurs in number patients precluding long-term application these patients. Non-coding RNAs have been shown influence response cancer cells this agent via different mechanisms. Mechanistically, transcripts regulate expression several genes particularly those being involved the apoptotic processes. Lots vivo and vitro assays demonstrated efficacy oligonucleotide-mediated microRNAs (miRNA)/ long non-coding (lncRNA) silencing enhancement paclitaxel. Therefore, targeted therapies suggested as applicable modalities combatting agent. present review, we provide summary studies which assessed role miRNAs lncRNAs conferring